The National Institute for Occupational Safety and Health (NIOSH) is pleased to present Building a Safety Program to Protect the Nanotechnology Workforce: A Guide for Small to Medium-Sized Enterprises. Responsible development of nanotechnologies includes considering and managing the potential, unintended consequences to human health and the environment that might accompany development and use of the technology. This guide will demonstrate that the key to ensuring the safety of your business, particularly when resources are limited, is to prevent occupational exposures and incidents before they happen.